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How is Depakote excreted? Valproate is metabolized almost entirely by the liver. In adult patients on monotherapy, 30-50% of an administered dose appears in urine as a glucuronide conjugate. Mitochondrial β-oxidation is the other major metabolic pathway, typically accounting for over 40% of the dose.
Can you crush extended release tablets? The majority of extended - release products should not be crushed or chewed, although there are some newer slow- release tablet formulations available that are scored and can be divided or halved (e.g., Toprol XL). Some patients have difficulty swallowing tablets or capsules; some dislike the taste.
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